3 things about 2-bromo-3-methylpropiophenone: Synthesis, purification and purchase

Cas 1451-82-7

How is 2-bromo-3-methylpropiophenone synthesized?

To synthesize 2-bromo-3-methylpropiophenone, you can follow the following steps:

1. Start with acetophenone as the starting material. Acetophenone can be obtained commercially or synthesized through the Friedel-Crafts acylation reaction of benzene with acetyl chloride in the presence of a Lewis acid catalyst.

2. React acetophenone with bromine in the presence of a Lewis acid catalyst such as aluminum bromide (AlBr3) to brominate the aromatic ring. The bromine will substitute the hydrogen at the ortho position relative to the carbonyl group, leading to the formation of 2-bromoacetophenone.

3. Next, react the 2-bromoacetophenone with methylmagnesium bromide (CH3MgBr) in an anhydrous solvent such as diethyl ether to introduce the methyl group at the para position relative to the carbonyl group. This will yield 2-bromo-3-methylpropiophenone.

4. Finally, purify the product through recrystallization or column chromatography to obtain pure 2-bromo-3-methylpropiophenone.

2-Bromo-4-Methylpropiophenone | CAS 1451-82-7
2-Bromo-4-Methylpropiophenone | CAS 1451-82-7

Overall, the synthesis of 2-bromo-3-methylpropiophenone involves brominating acetophenone followed by a Grignard reaction with methylmagnesium bromide to introduce the methyl group.

How is 2-bromo-3-methylpropiophenone purified?

One common method to purify 2-bromo-3-methylpropiophenone is through recrystallization. Here is a general outline of how recrystallization can be used to purify the compound:

1. Dissolve the crude 2-bromo-3-methylpropiophenone in a minimum amount of a suitable solvent at an elevated temperature. The choice of solvent will depend on the solubility of the compound and impurities. Common solvents for recrystallization include ethanol, methanol, and acetone.

2. Once the compound is completely dissolved, slowly cool the solution to room temperature or below. This allows the compound to slowly come out of solution and form crystals.

3. After the solution has cooled, place it in an ice bath or refrigerator to further encourage crystal formation. The slower the cooling process, the larger and purer the crystals will be.

4. Filter the cooled solution to separate the solid crystals from the mother liquor (the leftover liquid). Use a vacuum filtration setup or gravity filtration with filter paper to collect the crystals.

5. Wash the collected crystals with a small amount of ice-cold solvent to remove any remaining impurities. This step can help further purify the compound.

6. Allow the crystals to air dry or use a desiccator to remove any remaining solvent. The collected crystals are now purified 2-bromo-3-methylpropiophenone.

Cas 1451-82-7/2-bromo-3-methylpropiophenone

The purity of the compound can be confirmed by techniques such as thin-layer chromatography (TLC) or melting point determination. Recrystallization is a simple and effective method for purifying organic compounds and is commonly used in organic synthesis laboratories.

Where to buy 2-bromo-3-methylpropiophenone in large quantities?

Hubei Aumei New Material Co., Ltd is a leading manufacturer and supplier specializing in high-quality pharmaceutical and organic chemicals, with a focus on pharmaceutical intermediates, raw materials, and fine chemicals. Committed to ethical business practices, we prioritize delivering superior products globally.

Cas 1451-82-7/2-bromo-3-methylpropiophenone

Our state-of-the-art facilities, operated by experienced professionals, ensure strict quality control and adherence to industry standards. Successfully exporting to numerous countries, including the Netherlands, Poland, Germany, USA, Canada, the UK, Australia, Mexico, France, Italy, etc., our products consistently exceed expectations.

Driven by a commitment to excellence, we collaborate closely with research institutions to provide tailored solutions. Our dedicated team of scientists explores innovative methodologies to deliver customized products and services that address the unique challenges faced by our clients.

Choose Aumei for reliable, transparent, and growth-oriented partnerships.

3 things to know about 2-Bromo-1-phenylpentan-1-one

2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2

How is 2 Bromo 1 phenyl 1 pentanone synthesized?

2-Bromo-1-phenylpentan-1-one, also known as α-Bromovalerophenone, is synthesized through a straightforward process. Here’s a simplified description of its synthesis:

2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2
2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2
  1. Starting Materials:
    • Phenylpentanone: Begin with phenylpentanone, which is a ketone compound with a phenyl group attached to a pentanone backbone.
    • Sodium Bromide (NaBr): Sodium bromide serves as the bromine source in the reaction.
  2. Reaction Steps:
    • At room temperature, combine 16.2 grams (0.1 moles) of phenylpentanone and 30.9 grams (0.3 moles) of sodium bromide in a reaction flask.
    • Stir the mixture evenly to ensure thorough mixing.
  3. Bromination Reaction:
    • The bromine atom from sodium bromide replaces one of the hydrogen atoms on the phenylpentanone molecule.
    • This substitution reaction results in the formation of 2-bromo-1-phenylpentan-1-one.
  4. Product Isolation:
    • The product can be isolated by various methods, such as extraction or distillation.
    • Purify the compound to obtain the desired α-bromovalerophenone.
  5. Applications:

What should I do if 2-Bromo-1-phenylpentan-1-one gets on my skin?

If 2-Bromo-1-phenylpentan-1-one (also known as α-Bromovalerophenone) comes into contact with your skin, follow these safety precautions:

2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2
2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2
  1. Immediate Action:
    • Rinse the affected area with plenty of water. Use a gentle stream to wash off any residual compound.
    • Remove contaminated clothing if applicable.
  2. Seek Medical Attention:
    • Seek medical assistance promptly. Contact a healthcare professional or visit an emergency room.
    • Provide information about the exposure to the medical staff.
  3. Avoid Further Exposure:
    • Do not rub or scrub the skin vigorously. Gentle rinsing is sufficient.
    • Avoid touching your face, eyes, or mouth with contaminated hands.
  4. Personal Protective Measures:
    • Wear disposable gloves if available.
    • Use a mild soap to cleanse the skin gently.
  5. Observe for Symptoms:
    • Monitor the affected area for any signs of irritation, redness, or discomfort.
    • Report any adverse symptoms to the medical professionals.
  6. Safety Data Sheet (SDS):

Can it be disposed of in the sink or toilet?

2-Bromo-1-phenylpentan-1-one (α-Bromovalerophenone) should not be disposed of in the sink or toilet. It is essential to follow proper disposal procedures to prevent environmental contamination and ensure safety. Here are the recommended steps for disposal:

Hubei Aumei New Material Co., Ltd
Hubei Aumei New Material Co., Ltd Sell 2-Bromo-1-phenylpentan-1-one
  1. Chemical Waste Collection:
    • Collect the compound in a suitable container designated for chemical waste disposal.
    • Label the container with the name of the compound and any relevant hazard information.
  2. Contact Local Authorities or Waste Management Services:
    • Contact your local waste management facility or authorities to inquire about hazardous waste disposal regulations.
    • They will provide guidance on how to dispose of the compound safely.
  3. Do Not Pour Down the Sink or Toilet:
    • Avoid pouring the compound down the sink or toilet. It can contaminate water sources and harm the environment.
  4. Secure Storage:
    • Store the waste container securely in a well-ventilated area away from direct sunlight and heat.
  5. Professional Disposal:
    • Arrange for professional disposal through authorized waste disposal services.
    • They will handle the compound according to safety protocols.

Difference between Pharmaceutical Intermediates and APIs

cas 374675-21-5

What is a Pharmaceutical Intermediate? What is the difference between it and API? Pharmaceutical intermediates and APIs both belong to the category of fine chemicals.

2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2
2-Bromo-1-phenyl-1-pentanone | CAS 49851-31-2

Difference in definition between pharmaceutical intermediates and APIs

Pharmaceutical intermediates: materials produced in the process steps of an API that must undergo further molecular changes or refinement to become a material for the API. Intermediates may or may not be separated.

API: Active Pharmaceutical Ingredient, any substance or mixture of substances used in the manufacture of a drug that becomes the active ingredient of the drug. The substance is pharmacologically active or otherwise has a direct effect on the diagnosis, treatment, symptomatic relief, cure, or prevention of disease, or may affect the function and structure of the body.

cas 374675-21-5
cas 374675-21-5

Active Pharmaceutical Any substance or mixture of substances used in the manufacture of a medicinal product which, when used in a medicinal product, becomes the active substance of the medicinal product. The substance has a pharmacologic or other direct role in disease diagnosis, symptom relief, treatment, or disease prevention, or may affect the function and structure of the body. A drug is an active product that has completed its synthetic pathway, and a pharmaceutical intermediate is a product somewhere in the synthetic pathway.

APIs can be produced directly, whereas intermediates can only be used to synthesize the next product, and APIs can only be produced through intermediates. This definition suggests that an intermediate is a key product of the previous process of preparing an API and is structurally different from the API. In addition, the Pharmacopoeia contains assays for APIs but not intermediates.

cas 374675-21-5
cas 374675-21-5

Differences from the perspective of drug development

Looking at the difference between the two from the point of view of new drug development, APIs are those that have undergone sufficient pharmacological research to be safe for therapeutic and diagnostic use in humans. Pharmaceutical intermediates are compounds in the process of synthesizing APIs that are not necessarily therapeutically effective or toxic. Please note that this does not necessarily mean that some intermediates in the synthesis process of APIs are also APIs.

Differences between pharmaceutical intermediates and APIs in terms of certification

Regarding certification, the FDA requires intermediates to be registered, not COS. however, the CTD document should contain a detailed process description of the intermediate. APIs (APIs) If an API company submits a very simple synthetic route for an API, the FDA considers the risk control insufficient if there is only one step of the reaction and is likely to extend the inspection of the intermediates. Intermediate management is generally based on ISO or Q7a, which allows for quality system management.

Acetaminophen | CAS 103-90-2
Acetaminophen | CAS 103-90-2

Difference between the two from the perspective of drug administration

Regarding drug management, APIs should apply for registration with the Food and Drug Administration (SFDA in China, FDA in the US, and EMA in Europe) according to the law, and synthesize in GMP-compliant factories after obtaining the approval number.

Intermediates are just intermediate products in the process of synthesizing APIs and do not need to obtain a document number. It should be noted that compounds that are identical to APIs do not obtain a document number and are not produced in GMP plants.

Pharmaceutical intermediates do not need production licenses such as APIs, the entry threshold is relatively low and competition is fierce. As a result, quality, scale, and management level are often the basis for company survival and development. Increased pressure on environmental protection has also led to the gradual withdrawal of many small companies from the competitive stage, and industry concentration is expected to increase rapidly.

How to improve the profitability of a pharmaceutical intermediates company?

It is generally recognized that the following three directions will be key to improving profitability, adding value, and sustaining growth for the companies concerned:

(1) Product diversification from large-scale low-end intermediates to fine intermediates production;

(2) Taking the road of specialized outsourcing services, further expanding the outsourcing service industry chain, and taking over the R&D outsourcing services;

(3) Focusing on the production of APIs and intermediate preparations;

6 Things You Need To Know About PMK Ethyl Glycidate

pmk oil cas 28578-16-7

PMK ethyl glycidate, with CAS number 28578-16-7, is a pharmaceutical intermediate used in the synthesis of various drugs, including MDMA. Here are some of the most popular and specialized questions about PMK ethyl glycidate along with detailed answers:

pmk oil cas 28578-16-7 PMK Ethyl Glycidate

What is PMK ethyl glycidate used for?
PMK ethyl glycidate is primarily used as a precursor in the synthesis of drugs like MDMA. It serves as a key intermediate in the production process of MDMA due to its ability to be converted into safrole, a crucial component in MDMA synthesis.

Is PMK ethyl glycidate legal?
PMK ethyl glycidate is a controlled substance and is subject to strict regulations due to its potential use in the illegal production of drugs like MDMA. The production, distribution, and use of PMK ethyl glycidate are closely monitored by law enforcement agencies in many countries.

How is PMK ethyl glycidate synthesized?
PMK ethyl glycidate is typically synthesized through the reaction of PMK glycidate with ethyl alcohol. This synthesis process involves specific chemical reactions and conditions to produce PMK ethyl glycidate, an important intermediate in drug synthesis.

What are the risks associated with PMK ethyl glycidate?
As a controlled substance, PMK ethyl glycidate poses various risks, especially when used in the production of illicit drugs. The unauthorized production and distribution of PMK ethyl glycidate can lead to legal consequences. Improper handling of PMK ethyl glycidate can also result in health hazards, such as chemical burns and respiratory issues.

Can PMK ethyl glycidate be purchased online?
Due to its status as a controlled substance, it is illegal to purchase PMK ethyl glycidate online without the appropriate authorization. Individuals seeking PMK ethyl glycidate for legitimate research or industrial purposes must comply with regulations and obtain the necessary permits and licenses.

Hubei Aumei New Material Co., Ltd
Hubei Aumei New Material Co., Ltd

What precautions should be taken when working with PMK ethyl glycidate?
When handling PMK ethyl glycidate, it is crucial to take precautions to ensure safety and regulatory compliance. This includes wearing proper personal protective equipment, working in a well-ventilated area, and following correct handling and storage procedures to minimize risks associated with the substance.

In summary, PMK ethyl glycidate is a pharmaceutical intermediate product used in drug synthesis, including MDMA. It is essential to understand the legal implications, risks, and safety measures associated with PMK ethyl glycidate to ensure proper handling and compliance with regulations.

The Ultimate Guide to BMK Glycidic Acid (CAS 5449-12-7):

BMK Powder | CAS 5449-12-7

BMK Glycidic Acid, also known as CAS 5449-12-7, is a pharmaceutical intermediate product that plays a crucial role in the synthesis of various drugs. This versatile compound is widely used in the pharmaceutical industry for its unique properties and applications. On Google, there are several popular and specialized questions and answers about CAS 5449-12-7. In this article, we will summarize some of these questions and provide detailed answers to help you understand more about this pharmaceutical intermediate product.

BMK Glycidic Acid | CAS 5449-12-7
BMK Powder | CAS 5449-12-7

1. What is CAS 5449-12-7?

CAS 5449-12-7, also known by its chemical name CAS 5449-12-7, is a pharmaceutical intermediate product that is commonly used in the synthesis of drugs. It is a key compound in the production of various pharmaceuticals due to its reactivity and functional groups.

2. How is CAS 5449-12-7 synthesized?

CAS 5449-12-7 is typically synthesized through the oxidation of benzyl methyl ketone (BMK) using strong oxidizing agents. The oxidation process converts BMK into BMK Glycidic Acid, which is then purified and isolated to obtain the final product. This compound is essential for the synthesis of certain drugs due to its unique chemical structure.

3. What are the key properties of CAS 5449-12-7?

CAS 5449-12-7 is a solid compound that is typically white or off-white in color. It is sparingly soluble in water but more soluble in organic solvents. This compound has a molecular formula of C10H10O3 and a molecular weight of approximately 178.19 g/mol. It is important to consider the physical and chemical properties of BMK Glycidic Acid when using it in drug synthesis.

4. What are the common uses of BMK Glycidic Acid?

BMK Glycidic Acid (CAS 5449-12-7) is primarily used as a pharmaceutical intermediate product in the synthesis of drugs. It serves as a key precursor in the production of various pharmaceutical compounds, including analgesics, stimulants, and other medications. The unique chemical structure of BMK Glycidic Acid allows for the formation of complex drug molecules.

5. Are there safety precautions to consider when handling CAS 5449-12-7?

When working with CAS 5449-12-7, it is important to take necessary safety precautions to prevent exposure. This compound may pose health hazards if not handled properly, such as skin irritation or respiratory effects. Protective equipment, such as gloves and goggles, should be worn when handling BMK Glycidic Acid. Proper ventilation and waste disposal procedures should also be followed to ensure safety.

6. How is BMK Glycidic Acid stored?

To maintain the stability and integrity of CAS 5449-12-7, it should be stored in a cool, dry place away from direct sunlight and heat sources. The storage container should be tightly sealed to prevent contamination or degradation of the compound. It is important to follow specific storage guidelines to preserve the quality of BMK Glycidic Acid for pharmaceutical synthesis.

7. Can CAS 5449-12-7 be used in academic or research settings?

CAS 5449-12-7 is commonly used in academic and research settings for the synthesis of pharmaceutical compounds. Researchers and scientists utilize this compound to explore new drug formulations and study its chemical reactivity. When using CAS 5449-12-7 in research, it is essential to adhere to safety protocols and regulations to ensure proper handling and disposal.

In conclusion, CAS 5449-12-7 is a pharmaceutical intermediate product with significant importance in drug synthesis. Its unique properties and applications make it a valuable compound in the pharmaceutical industry. By understanding the synthesis, properties, uses, safety precautions, and storage requirements of BMK Glycidic Acid, researchers and professionals can effectively utilize this compound in the development of novel pharmaceuticals.

CAS 20320-59-6: Everything You Need to Know

BMK Oil | CAS 20320-59-6

Diethyl(phenylacetyl)malonate, also known as CAS 20320-59-6, is a pharmaceutical intermediate product that is commonly used in the synthesis of various drugs. It is a versatile compound that has a wide range of applications in the pharmaceutical industry. Due to its importance in drug synthesis, there are many questions and answers about this compound on Google. In this article, we will summarize the more popular and specialized questions and answers about Diethyl(phenylacetyl)malonate.

bmk oil cas 20320-59-6

1. What is CAS 20320-59-6?

CAS 20320-59-6, also known as diethyl(phenylacetyl)malonate, is a chemical compound that is used as a pharmaceutical intermediate product. It is commonly used in the synthesis of various drugs due to its versatile nature and ability to react with other compounds to form new substances.

2. What are the properties of Diethyl(phenylacetyl)malonate

Diethyl(phenylacetyl)malonate is a white to off-white solid that is insoluble in water but soluble in organic solvents. It has a molecular formula of C15H18O5 and a molecular weight of 278.3 g/mol. It has a melting point of around 45-50°C and a boiling point of around 380-400°C.

3. What are the uses of CAS 20320-59-6?

CAS 20320-59-6 is primarily used as a pharmaceutical intermediate product in the synthesis of various drugs. It is commonly used in the production of analgesics, anti-inflammatory agents, and other pharmaceutical compounds. It is also used in the synthesis of perfumes and flavorings.

bmk oil cas 20320-59-6

4. How is Diethyl(phenylacetyl)malonate synthesized?

Diethyl(phenylacetyl)malonate is synthesized through the reaction of phenylacetic acid with diethyl malonate in the presence of a base catalyst. The reaction typically takes place at elevated temperatures and under inert atmosphere to prevent side reactions. The resulting product is then purified and isolated to obtain pure diethyl(phenylacetyl)malonate.

5. What are the safety precautions associated with handling CAS 20320-59-6?

CAS 20320-59-6 should be handled with care as it is a chemical compound that can be hazardous if not handled properly. It is important to wear appropriate personal protective equipment, such as gloves and goggles, when handling this compound. It should be stored in a cool, dry place away from heat and sources of ignition. In case of skin contact or ingestion, medical attention should be sought immediately.

6. Are there any regulations or restrictions on the use of CAS 20320-59-6?

As a chemical compound, CAS 20320-59-6 is subject to regulations and restrictions imposed by regulatory authorities. It is important to adhere to these regulations and ensure that the compound is used in accordance with the guidelines set forth by the relevant authorities. It is also important to conduct proper risk assessments and implement appropriate control measures when working with this compound.

7. What are the potential side effects or hazards associated with Diethyl(phenylacetyl)malonate?

Diethyl(phenylacetyl)malonate is a chemical compound that can pose certain hazards if not handled properly. It may cause irritation to the skin, eyes, and respiratory tract upon exposure. It may also be harmful if ingested or inhaled. It is important to be aware of these potential hazards and take appropriate precautions when working with this compound.

8. What are the storage and handling requirements for CAS 20320-59-6?

CAS 20320-59-6 should be stored in a cool, dry place away from heat and sources of ignition. It should be kept in a well-ventilated area and away from incompatible materials. It should be handled with care and appropriate personal protective equipment should be worn when handling this compound. Proper labeling and documentation are also important when storing and handling this compound.

9. Can CAS 20320-59-6 be used in research or academic settings?

CAS 20320-59-6 is commonly used in research and academic settings for the synthesis of various compounds. It is a versatile compound that can be used in the development of new drugs and pharmaceuticals. However, it is important to ensure that proper safety measures are in place when working with this compound in a research or academic setting.

In conclusion, CAS 20320-59-6 is a pharmaceutical intermediate product that is commonly used in the synthesis of various drugs. It is a versatile compound with a wide range of applications in the pharmaceutical industry. It is important to be aware of the properties, uses, safety precautions, regulations, and potential hazards associated with this compound when working with it. Proper storage and handling procedures should be followed to ensure the safe and effective use of CAS 20320-59-6 in pharmaceutical synthesis and research.

Who are the manufacturers of High Purity Pharmaceutical Intermediates in China?

In recent years, China has emerged as a major player in the manufacturing and supply of high purity pharmaceutical intermediates. Among the many manufacturers in China, Hubei Aumei New Material Co., Ltd. stands out as a leading company specializing in high-quality pharmaceutical and organic chemicals. With a strong focus on pharmaceutical intermediates, raw materials, and fine chemicals, Hubei Aumei New Material Co., Ltd. is committed to delivering superior products globally.

Hubei Aumei New Material Co., Ltd
Hubei Aumei New Material Co., Ltd

Hubei Aumei New Material Co., Ltd. offers a wide range of High Purity Pharmaceutical Intermediates, each with their own unique cas numbers. Some of the key products offered by the company include cas 20320-59-6, cas 5449-12-7, cas 28578-16-7, cas 49851-31-2, cas 1451-82-7, cas 1451-83-8, cas 236117-38-7, cas 59774-06-0, cas 5337-93-9, and cas 52190-28-0. These High Purity Pharmaceutical Intermediates are essential for the synthesis of various pharmaceutical products and play a crucial role in the pharmaceutical industry.

High Purity Pharmaceutical Intermediates BMK Powder | CAS 5449-12-7
BMK Powder | CAS 5449-12-7

In addition to the high purity pharmaceutical intermediates mentioned earlier, Hubei Aumei New Material Co., Ltd. offers a diverse range of specialized chemical compounds that cater to various industries. These compounds are meticulously formulated using cutting-edge technologies and adhere to stringent quality control measures to ensure their purity and consistency.

Moreover, Hubei Aumei New Material Co., Ltd. prides itself on its state-of-the-art production facilities, equipped with advanced machinery and operated by highly skilled professionals. The company’s commitment to innovation and research ensures the development of novel chemical compounds that meet the evolving needs of the pharmaceutical industry.

Customers can also benefit from the company’s customized solutions, tailored to their specific requirements. Whether it is a unique chemical compound or a specialized formulation, Hubei Aumei New Material Co., Ltd. can work closely with customers to develop a product that aligns with their individual needs.

Furthermore, the company’s dedication to sustainability and environmentally-friendly practices sets it apart in the industry. Hubei Aumei New Material Co., Ltd. prioritizes eco-friendly manufacturing processes and packaging materials, ensuring minimal impact on the environment while delivering high-quality products.

Additionally, the company’s strong emphasis on quality assurance and compliance with industry standards guarantees that customers receive products that meet or exceed regulatory requirements. Hubei Aumei New Material Co., Ltd. has earned a reputation for reliability and consistency, making it a preferred choice for customers seeking top-notch high purity pharmaceutical intermediates.

In conclusion, Hubei Aumei New Material Co., Ltd. is a leading manufacturer of high purity pharmaceutical intermediates, offering a comprehensive range of products, services, and solutions to meet the diverse needs of the pharmaceutical industry. With a focus on innovation, quality, and sustainability, the company remains at the forefront of the chemical manufacturing sector, delivering unparalleled value to its customers. Choose Hubei Aumei New Material Co., Ltd. for your pharmaceutical intermediate requirements and experience excellence in every product.