3 things about 2-bromo-3-methylpropiophenone: Synthesis, purification and purchase

How is 2-bromo-3-methylpropiophenone synthesized?

To synthesize 2-bromo-3-methylpropiophenone, you can follow the following steps:

1. Start with acetophenone as the starting material. Acetophenone can be obtained commercially or synthesized through the Friedel-Crafts acylation reaction of benzene with acetyl chloride in the presence of a Lewis acid catalyst.

2. React acetophenone with bromine in the presence of a Lewis acid catalyst such as aluminum bromide (AlBr3) to brominate the aromatic ring. The bromine will substitute the hydrogen at the ortho position relative to the carbonyl group, leading to the formation of 2-bromoacetophenone.

3. Next, react the 2-bromoacetophenone with methylmagnesium bromide (CH3MgBr) in an anhydrous solvent such as diethyl ether to introduce the methyl group at the para position relative to the carbonyl group. This will yield 2-bromo-3-methylpropiophenone.

4. Finally, purify the product through recrystallization or column chromatography to obtain pure 2-bromo-3-methylpropiophenone.

2-Bromo-4-Methylpropiophenone | CAS 1451-82-7
2-Bromo-4-Methylpropiophenone | CAS 1451-82-7

Overall, the synthesis of 2-bromo-3-methylpropiophenone involves brominating acetophenone followed by a Grignard reaction with methylmagnesium bromide to introduce the methyl group.

How is 2-bromo-3-methylpropiophenone purified?

One common method to purify 2-bromo-3-methylpropiophenone is through recrystallization. Here is a general outline of how recrystallization can be used to purify the compound:

1. Dissolve the crude 2-bromo-3-methylpropiophenone in a minimum amount of a suitable solvent at an elevated temperature. The choice of solvent will depend on the solubility of the compound and impurities. Common solvents for recrystallization include ethanol, methanol, and acetone.

2. Once the compound is completely dissolved, slowly cool the solution to room temperature or below. This allows the compound to slowly come out of solution and form crystals.

3. After the solution has cooled, place it in an ice bath or refrigerator to further encourage crystal formation. The slower the cooling process, the larger and purer the crystals will be.

4. Filter the cooled solution to separate the solid crystals from the mother liquor (the leftover liquid). Use a vacuum filtration setup or gravity filtration with filter paper to collect the crystals.

5. Wash the collected crystals with a small amount of ice-cold solvent to remove any remaining impurities. This step can help further purify the compound.

6. Allow the crystals to air dry or use a desiccator to remove any remaining solvent. The collected crystals are now purified 2-bromo-3-methylpropiophenone.

Cas 1451-82-7/2-bromo-3-methylpropiophenone

The purity of the compound can be confirmed by techniques such as thin-layer chromatography (TLC) or melting point determination. Recrystallization is a simple and effective method for purifying organic compounds and is commonly used in organic synthesis laboratories.

Where to buy 2-bromo-3-methylpropiophenone in large quantities?

Hubei Aumei New Material Co., Ltd is a leading manufacturer and supplier specializing in high-quality pharmaceutical and organic chemicals, with a focus on pharmaceutical intermediates, raw materials, and fine chemicals. Committed to ethical business practices, we prioritize delivering superior products globally.

Cas 1451-82-7/2-bromo-3-methylpropiophenone

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